Suture in Space: ready for phase 2

16 December 2022 - Research -

The experiment which aims to study the repair mechanisms of tissues and the healing of wounds in the absence of gravity is now ready for the second step, in which the ASAcampus Joint Laboratory will have a pivotal role: the analysis of the biological samples, which will be sent back to earth in early 2023. The first feedback is expected within the space of a year.

After reaching the International Space Station (ISS) on 26th November last, the “Suture in Space” experiment, coordinated by the University of Florence and curated by Doctor Monica Monici, in charge of the ASAcampus Joint Laboratory – born from the partnership between ASA’s Research Division and the “Mario Serio” Experimental and Clinical Biomedical Sciences Department of the University of Florence – is now ready for the second phase.

The results of the project which aims to study the repair mechanisms of tissues and the healing of wounds in the absence of gravity will be very useful for daily life on earth as well.

“During the first phase – says Monica Monici, Scientific Head of the project chosen by the European Space Agency (ESA) and financed by the Italian Space Agency (ASI) – we developed some models of sutured wounds based, to our knowledge for the first time ever, on ex-vivo cultures of human tissue, skin and blood vessels. To maintain their survival and functions for a long time, we developed an in-vitro culture technique which maintains their vigour for 5 weeks. This specific technique can also be used for many applications here on Earth too in the fields of Tissue Engineering and Regenerative Medicine, as well as for preliminary studies concerning the effects of medicines. All this whilst avoiding, for some tests, the use of animals”.

Once prepared, the samples were sent into Space with a distinct purpose: to help understand some aspects of the wound recovery and the tissue repair processes that studies on earth have not yet fully cleared up. 

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Campioni biologici - Suture in Space

“Suture in Space” can assist us to better understand what the dysfunctions of these processes are and therefore help us to develop new therapeutic strategies that can be applied to our daily lives”. 

One example will suffice: this study could help identify the reasons for the healing delay in chronic ulcers or fibrosis, widespread pathologies which are very costly for National Health Services.

The second phase of the project will consist precisely in the analysis of the sample results, which have been frozen on the Space Station and will be sent back to Earth in early January. 
However, to obtain all the results, at least a one-year wait will be required as this second phase is in turn divided into several steps: not only will a series of control tests need to be carried out on Earth, but all the biological samples will have to be divided and shared with the various Italian and European research groups involved in the project.

“Each group - concludes Monici who has curated the experiment over the past 7 years together with ASAcampus researchers Francesca Cialdai and Chiara Risaliti – has specific analyses to carry out on these portions of tissue. We will then have to collect all the data and create an overall picture of the results”.

Interview with Doctor Monica Monici

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